CASE REPORT: LONGITUDINAL MONITORING OF CLONAL EVOLUTION BY CIRCULATING TUMOR DNA FOR RESISTANCE TO ANTI-EGFR ANTIBODY IN A CASE OF METASTATIC COLORECTAL CANCER

BackgroundTreatment with anti-EGFR antibody has been shown to prolong survival in patients with RAS wild-type metastatic colorectal cancer (mCRC).However, even patients who initially respond to anti-EGFR antibody therapy, almost without exception, develop resistance to the therapy and then fail to respond.Secondary mutations in the Matting/Signage

This case is the first documented instance of genitourinary monkeypox (Mpox) diagnosed by a urology service in Mexico, emphasizing the role of urologists in managing atypical genitourinary infections.A 28-year-old Flux Core Wire homosexual male with HIV developed penile swelling and pustular lesions, confirmed as MPXV infection by PCR.Symptomatic m

Plant seeds are the resources of many different Storage Tins bioactive components.The chemical composition of the different crude extracts from Benincasa hispida (White pumpkin) and Cucurbita moschata (Pumpkin) seeds with three different polarity-based solvents (n-hexane, n-hexane-chloroform (2:1), and methanol) was analyzed to identify the biologi

Cultural transmission biases such as prestige are thought to have been a primary driver in shaping the dynamics of human cultural evolution.However, few empirical studies have measured the importance of prestige Matting/Signage relative to other effects, such as content biases present within the information being transmitted.Here, we report the fin

The research studies the melody and rhythmic characteristics in the songs of the Baghdadi quartet, as it is Matting/Signage a type of popular singing in Iraq, reviewing its origins, social purposes, special and public events in which it is performed.The methodological framework included the problem of the research, the need for it, its importance,